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Geometry Points to Coronavirus Drug Target Candidates

By Scientific American

May 20, 2020

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A study by Robert Penner at France’s Institute of Advanced Scientific Studies incorporates a mathematical model that predicts protein sites on viruses that might be particularly susceptible to disabling treatments, which has been used to identify potential drug and vaccine targets in the fight against the coronavirus that causes COVID-19.

The technique exploits the fact that certain viral proteins change shape when viruses penetrate cells; Penner mathematically localized exotic sites that mediate this shift.

John Yin, who studies viruses at the University of Wisconsin–Madison, said much work remains to verify the study’s predictions through experimentation.

Said Arndt Benecke, a biological researcher at the French National Center for Scientific Research, “This could go far beyond the viruses.”

From Scientific American
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