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Computer System Can Help Inform Future Therapies for Patients with Inherited Heart Disease

By News-Medical Life Sciences

June 14, 2021

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A computer system trained on clinical data can provide support for medical and surgical decisions on future treatment for patients with inherited heart disease.

Scientists at the Wellcome Sanger Institute and University of Cambridge in the U.K., the Massachusetts Institute of Technology (MIT) in the U.S., and Sweden's Lund University engineered the model from genomic data combined with biological and chemical data, then validated it with global data from more than 980 patients with inherited heart muscle disease.

The model can forecast how genetic variants may influence changes in troponins, or proteins involved in inherited cardiomyopathies.

MIT's Rameen Shakur said, "This study is the next step in integrating precision cardiology into clinical care, and working more closely with clinical genetics colleagues and patients with their families, bridging the gap between research and day-to-day treatment decisions."

From News-Medical Life Sciences
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