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Leveraging AI to Work with Cells

By Northwestern University McCormick School of Engineering

March 24, 2022

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Researchers at Northwestern University developed a new version of their Nanofountain Probe Electroporation (NFP-E) tool to execute cell engineering tasks using artificial intelligence, which could help develop personalized diagnostics and treatments.

The NFP-E is used to insert materials into cells and selectively manipulate single cells in micro-arrays.

The researchers updated the tool to automate processes like cell nuclei localization, probe detection, probe motion, probe-to-cell contact detection, and electroporation-mediated delivery of foreign cargo into single cells.

The automated NFP-E can perform selective cell engineering at higher throughputs than manual probe-based methods, at the same time minimizing experimental variability and allowing for more efficient engineering of human induced pluripotent stem cells (hiPSCs).

Said Northwestern's Horacio Espinosa, "The idea is to establish a fully automated cell line generation workflow using the combination of the NFP-E and the micro-well arrays."

From Northwestern University McCormick School of Engineering
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