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Organoid Intelligence: Computing on the Brain

By IEEE Spectrum

April 24, 2023

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Researchers have proposed using brain organoids—spherical masses cultured from neural tissue—as computational systems.

Underlying the so-called organoid intelligence initiative are induced pluripotent stem cells (IPSCs) and three-dimensional (3D) cell culturing methods.

Biologists can use new 3D-scaffolding techniques to grow IPSC-derived neural tissues vertically and horizontally, allowing organoids to evolve the interneuronal networks observed in animal brains.

The University of California, San Diego's Alysson Muotri believes organoids' mimicry of the network and cellular architecture of specific cortical and subcortical structures may facilitate the information processing capabilities of brain tissue.

Multielectrode arrays wrapped around organoids can record neuron activity so researchers can deduce neuronal communication mechanisms via causal modeling.

From IEEE Spectrum
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